ABSTRACT
Family with sequence similarity 20,member C(FAM20C),also known as dentin matrix protein 4 (DMP4),is a calcium-binding kinase for secreted phosphoproteins,and is highly expressed in mineralized tissues,which phosphorylates secretory calcium-binding phosphoproteins (SCPPs),thus modulating biomineralization.Mutations in FAM20C may cause the Raine syndrome,an autosomal recessive disorder characterized by generalized osteosclerosis with teeth defects,bone defects,hypophosphatemia and neonatal lethality.FAM20C plays an important role in the osteogenesis and odontogenesis through regulating the differentiation of osteoblast,ameloblast and odontoblast,as well as suppressing the production of phosphate-regulating hormone fibroblast growth factor 23 (FGF23).The research progress on the function of FAM20C in osteogenesis and odontogenesis is reviewed.